Ammonia → 5,6,7,8-Tetrahydroquinoline-8-carboxamide

Participants

Reaction Conditions

Reaction Steps

Methyl-5,6,7,8-tetrahydroquinoline-8-carboxylate (9 g.) was dissolved in methanol previously saturated with ammonia (270 ml.) and heated in a bomb at 100° C for 5 days. The solvent was removed and the residual oil triturated with hot petroleum ether (40°-60°). The resultant solid was filtered and then recrystallised from ethylacetate giving the title compound as colourless needles mpt. 132° C (5 g.) Found: C, 67.7; H, 7.1; N, 16.0% C10H12N2O requires: C, 6.8.1; H, 6.9; N, 15.9%.

Provenance & Evidence