HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus sulfide (P2S5) → 2-Methyl-8-cyano-5,6,7,8-tetrahydroquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus sulfide (P2S5) | HCID 14817 | — |
| Reactant | 2-Methyl-5,6,7,8-tetrahydroquinoline-8-carboxamide | HCID 12278968 | — |
| Product | 2-Methyl-8-cyano-5,6,7,8-tetrahydroquinoline | HCID 20358412 | — |
Reaction Steps
2-Methyl-5,6,7,8-tetrahydroquinoline-8-carboxamide was treated with P2S5 to give 2-methyl-8-cyano-5,6,7,8-tetrahydroquinoline which was treated with H2S (both reactions being carried out by the method described in Example 8 to give the title compound as colourless needles from ethylacetate (28%) m.p. 98° (Found: C, 64.32; H, 6.93; N, 13.52%, C11H14N2S requires: C, 64.04; H, 6.84; N, 13.58%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031102 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-6bfcb8a660fa46ba88e5cc23b601362f |
| Source note | uspto-grants-1977_06 |