HuagongsheHuagongshe Chemistry Print Report · For research reference only
Malonic Acid → 1,3-Dipropylpyrimidine-2,4,6(1H,3H,5H)-trione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Malonic Acid | HCID 867 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N,N'-Dipropylurea | HCID 69343 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | 1,3-Dipropylpyrimidine-2,4,6(1H,3H,5H)-trione | HCID 12470916 | — |
Reaction Steps
Synthesis was carried out according to the procedure of Goldner, Ann. Chem., 691, 142 (1966) using 1,3-di-n-propylurea (777 g., 5.38 mole), malonic acid (660 g., 6.34 mole), glacial acetic acid (1050 ml.) and acetic anhydride (2160 ml.) to obtain 790 g. (69.2%) of product, melting point 77° - 80° C. NMR and IR spectra were consistent with the assigned structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031218 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-713a4702711a4589846a6d9a408246de |
| Source note | uspto-grants-1977_06 |