HCID 21428710, compound → 4-(3-Methylphenoxy)piperidine

HRID 437557Notes

Reaction equation

HRID 437557 reaction equation
C([N:8]1[CH2:13][CH2:12][CH:11]([O:14][C:15]2[CH:16]=[C:17]([CH3:21])[CH:18]=[CH:19][CH:20]=2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C>[C:17]1([CH3:21])[CH:18]=[CH:19][CH:20]=[C:15]([O:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)[CH:16]=1

Participants

3

Reactant 1

HCID 21428710HCID 21428710, compound

Product 1

HCID 171967304-(3-Methylphenoxy)piperidine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By following the manipulative procedure described in Example 1(b), a solution of 16.6 g of 1-benzyl-4-(m-tolyloxy)piperidine in 105 ml. of ethanol produces a clear oil of 4-(m-tolyloxy)piperidine. The oil is dissolved in 150 ml. of ether, and 50 ml. of a saturated ethereal-HCl solution is slowly added. The salt precipitates out of solution, is collected, and dried. The salt is recrystallized from an ethanol and ether mixture to give white needles of the piperidine hydrochloride.

Sources & evidence

ORD record
ord-086ad7932aa948d7aa00bb133122183c
Source dataset
uspto-grants-1977_06
Patent number
US04031221

Reaction notes

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