HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phenyl chloroformate → 1-Phenoxycarbonyl-3-(p-fluorophenoxy)azetidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phenyl chloroformate | HCID 15891 | — |
| Reactant | 1-Benzhydryl-3-(4-fluorophenoxy)azetidine | HCID 15053369 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 1-Phenoxycarbonyl-3-(p-fluorophenoxy)azetidine | HCID 21428738 | — |
Reaction Steps
A solution of 20.0 g of 1-benzhydryl-3-(4-fluorophenoxy)azetidine and 10.3 g of phenylchloroformate in 200 ml. of toluene is refluxed for 16 hours. The reaction mixture is cooled, and the toluene is removed under reduced pressure to give a yellow oil. The oil is triturated with hexane to give a white solid of 1-phenoxycarbonyl-3-(p-fluorophenoxy)azetidine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031221 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-f1f12d4a48a34596b18ae613aeac5c68 |
| Source note | uspto-grants-1977_06 |