HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Fexinidazole Sulfone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-(Methylsulfonyl)phenol | HCID 123350 | — |
| Reactant | 2-(Chloromethyl)-1-methyl-5-nitro-1H-imidazole | HCID 13032133 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | Fexinidazole Sulfone | HCID 21429076 | — |
Reaction Steps
17.6 Grams (0.1 mole) of 1-methyl-2-chloromethyl-5-nitro-imidazole were heated for 2 hours at a temperature of from 50° to 60° C, while stirring thoroughly, as has been described in detail in Example 2 above, together with 17.2 g (0.1 mole) of 4-methylsulfonylphenol in 50 ml of dimethylacetamide, in the presence of 13.8 g (0.1 mole) of potassium carbonate. According to the processing method described in Example 1 above, 22.5 g (= 73% of the theory) of 1-methyl-2-(4-methylsulfonyl-phenoxymethyl)-5-nitro-imidazole were obtained in the form of white crystals having a melting point of 157° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04031232 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-2c608939de2c4e9c908c3e4467b73396 |
| Source note | uspto-grants-1977_06 |