N,N-bis(3-aminopropyl)methylamine → N,N-Bis-[3-(3,4-dihydro-1,3-dioxo-2-(1H)-isoquinolyl)-propyl]-methylamine

Participants

Reaction Steps

N,N-Bis-[3-(3,4-dihydro-1,3-dioxo-2-(1H)-isoquinolyl)-propyl]-methylamine was prepared analogous to Example 30 from 15 gm of isochroman-1,3-dione and N,N-bis-(3-amino-propyl)-methylamine. The hydrochloride was precipitated from acetone with ethereal hydrochloric acid and recrystallized from ethanol. M.p. of the hydrochloride: 202° -205° C; yield: 13.8 gm (32% of theory).

Provenance & Evidence