Iodoethane → HCID 21428663, compound

Participants

Reaction Steps

1.3 gm of N-[3-(3,4-dihydro-4,4-dimethyl-7-hydroxy-1,3-dioxo-2(1H)-isoquinolyl)-propyl]-N-[3-(3,4-dihydro-4,4-dimethyl-1,3-dioxo-2(1H)-isoquinolyl)-propyl]-methylamine were dissolved in 10 ml of absolute ethanol, the resulting solution was added to a solution of 0.06 gm of sodium in 10 ml of absolute ethanol, and 0.42 gm of ethyl iodide was added to the mixed solution. The mixture was refluxed for 30 minutes, another 0.42 gm of ethyl iodide was added, and the mixture was refluxed again for 30 minutes. The product was purified on a silicagel column (eluant: chloroform/ethanol = 25:1), and the hydrochloride was precipitated from acetone with ethereal hydrochloric acid. The hydrochloride sintered above 45° C; yield: 0.5 gm (35% of theory).

Provenance & Evidence