Benzene → HCID 21428867, compound

Participants

Reaction Steps

A mixture of 7.7 parts of 1-(2-thienylcarbonyl)aziridine, 11.5 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 8 parts of methanol and 54 parts of benzene is stirred and refluxed for 1.50 hours. The reaction mixture is cooled and dissolved in trichloromethane. The solution is washed twice with water, dried, filtered and evaporated. The residue is crystallized from methanol. The product is filtered off and dried, yielding 2 parts of N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-thiophenecarboxamide; mp. 194° C.

Provenance & Evidence