1-Phenyl-1,3,8-triazaspiro(4.5)decan-4-one → HCID 21428981, compound

Participants

Reaction Steps

A mixture of 1.2 parts of N-(2-bromoethyl)-2-nitrobenzamide, 1.15 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one and 45 parts of N,N-dimethylformamide is stirred and refluxed for 3 hours. After stirring is continued overnight at room temperature, N,N-dimethylformamide is evaporated in vacuo at 80° C. The residue is boiled in a mixture of 2-propanone and water and the unreacted starting material is filtered off. The filtrate is concentrated to half its volume and 2-propanol is added to the concentrate. The precipitated product is filtered off and dried, yielding 7 parts of 2-nitro-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)-ethyl]benzamide hydrobromide; mp. 259.4° C.

Provenance & Evidence