Methyl cis(+/-)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-4-carboxylate → Methyl cis(+/-)-2-(4-amino-3-methoxypiperidin-1-yl)-6-methylpyridine-4-carboxylate
Reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]([O:26][CH3:27])=[O:25])[CH:21]=[C:20]([CH3:28])[N:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:23]=[C:22]([C:24]([O:26][CH3:27])=[O:25])[CH:21]=[C:20]([CH3:28])[N:19]=2)[CH2:14][C@H:13]1[O:29][CH3:30]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The same operation as in Example (160c) was performed using methyl cis(±)-2-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-6-methylpyridine-4-carboxylate obtained in Example (166a) (38.8 mg) and a 10% palladium-carbon catalyst (40 mg), to obtain 23.9 mg of the title compound as a colorless oily substance. The resulting compound was used for the next reaction without purification.
Sources & evidence
- ORD record
- ord-def163d39a854039881e8f338a0c4490
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536197B2
Reaction notes
Loading…