5-Chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one → HCID 21428799, compound

Participants

Reaction Steps

A mixture of 1.5 parts of N-(2-bromoethyl)-2-nitrobenzamide, 1.55 parts of 5-chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one and 27 parts of N,N-dimethylformamide is stirred and refluxed for 5 hours. The reaction mixture is evaporated and the oily residue is crystallized from ethanol. The product is filtered off and dried, yielding 2.2 parts (67%) of N-{2-[4-(5-chloro-2,3-dihydro-2-oxo- 1H-benzimidazol-1-yl)-1-piperidinyl] ethyl}-2-nitrobenzamide hydrobromide. hemihydrate; mp. 273.2° C.

Provenance & Evidence