Methanol → HCID 21428964, compound

Participants

Reaction Steps

A mixture of 5.3 parts of N{2-[4-(2,3-dihydro-2-oxo- 1H-benzimidazol-1-yl)-1-piperidinyl] ethyl}-2-methoxy-4-nitrobenzamide in 80 parts of methanol and 90 parts of tetrahydrofuran is hydrogenated at normal pressure and at room temperature with 5 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filered off and the filtrate is evaporated. The residue is crystallized from ethanol 96%, yielding 3.65 parts of 4-amino-N{2-[4-(2,3-dihydro-2-oxo- 1H-benzimidazol-1-yl)-1-piperidinyl] ethyl}-2-methoxybenzamide hydrate; mp. 220.6° C.

Provenance & Evidence