反应详情

A mixture of 7.6 parts of 1-(2-nitrobenzoyl)aziridine, 8.46 parts of 4-(4-chlorophenyl)-4-piperidinol, 43.2 parts of benzene and 6.4 parts of methanol is stirred and refluxed for 1.50 hours. The reaction mixture is cooled and the product is extracted with trichloromethane. The extract is washed three times with water, dried, filtered and evaporated. The residue is converted into the hydrochloride salt in 2-propanone. The salt is filtered off and crystallized from a mixture of ethanol and 2,2'-oxybispropane. The product is filtered off and dried, yielding 6parts of N-{2-[4-(4-chlorophenyl)-4- hydroxy-1-piperidinyl]ethyl}-2-nitrobenzamide hydrochloride; mp. 174.1° C.

1. temperaturerefluxed for 1.50 hours
2. temperatureThe reaction mixture is cooled
3. extractionthe product is extracted with trichloromethane
4. washThe extract is washed three times with water
5. customdried
6. filtrationfiltered
7. customevaporated
8. filtrationThe salt is filtered off
9. customcrystallized from a mixture of ethanol and 2,2'-oxybispropane
10. filtrationThe product is filtered off
11. customdried