反应详情

To a stirred and cooled mixture of 32 parts of 2-bromoethanamine hydrobromide in 150 parts of water is added a solution of 23.5 parts of 4-fluoro-2-nitrobenzoyl chloride in 54 parts of benzene. While cooling to 0°-5° C and while stirring vigourously, there is added dropwise a solution of 13 parts of sodium hydroxide in 200 parts of water (exothermic reaction). Upon completion, stirring is continued for 2 hours at 0°-10° C. The precipitated product is filtered off, washed with water and dried, yielding 30 parts (93.6%) of N-(2-bromoethyl)-4-fluoro-2-nitrobenzamide.

1. temperaturecooled
2. temperatureWhile cooling to 0°-5° C
3. stirringwhile stirring vigourously
4. stirringUpon completion, stirring
5. filtrationThe precipitated product is filtered off
6. washwashed with water
7. customdried