Sodium Hydroxide → HCID 21428913, compound

Participants

Reaction Conditions

Reaction Steps

To a stirred solution of 21 parts of sodium hydroxide in 75 parts of water is added a solution of 29 parts of 2-chloroethanamine hydrochloride in 75 parts of water. The whole is stirred and heated for 10 minutes at 90° C. After cooling to 0° C, 19 parts of sodium hydrogen carbonate are added. While stirring vigorously, there is added dropwise, during a 45 minutes-period, a solution of 49 parts of 2,5-dichlorobenzoyl chloride in 75 parts of trichloromethane at a temperature below 0° C. Upon completion, stirring is continued for 30 minutes without cooling. The reaction mixture is warmed to 25° C and adjusted to pH 8 with a diluted sodium hydroxide solution. The product is extracted three times with trichloromethane. The combined extracts are washed three times with water, dried filtered and evaporated, yielding 62 parts of 1-(2,5-dichlorobenzoyl)-aziridine as a residue.

Provenance & Evidence