反应详情

A mixture of 72 parts of methyl 2-pyridinecarboxylate and 32 parts of 2-aminoethanol is stirred and refluxed carefully for 2 hours. The reaction mixture is cooled and poured onto water. The product is extracted five times with trichloromethane. The combined extracts are dried, filtered and evaporated, yielding 49 parts of N-(2-hydroxyethyl)-2-pyridinecarboxamide as a residue.

1. temperaturerefluxed carefully for 2 hours
2. temperatureThe reaction mixture is cooled
3. additionpoured onto water
4. extractionThe product is extracted five times with trichloromethane
5. customThe combined extracts are dried
6. filtrationfiltered
7. customevaporated