反应详情

To 49 parts of N-(2-hydroxyethyl)-2-pyridinecarboxamide are added dropwise 80 parts of sulfinyl chloride while stirring vigourously. Upon completion, stirring is continued first for 3 hours at reflux and further for 2 hours at room temperature. The excess of sulfinyl chloride is evaporated and the residue is poured onto hot methanol. After cooling, the precipitated product is filtered off (the filtrate is set aside) and washed thoroughly with 2,2'-oxybispropane, yielding a first fraction of 14 parts of N-(2-chloroethyl)-2-pyridinecarboxamide hydrochloride.

1. stirringUpon completion, stirring
2. customThe excess of sulfinyl chloride is evaporated
3. additionthe residue is poured onto hot methanol
4. temperatureAfter cooling
5. filtrationthe precipitated product is filtered off (the filtrate
6. washwashed thoroughly with 2,2'-oxybispropane