Potassium Iodide → HCID 21428904, compound

Participants

Reaction Steps

A mixture of 4.4 parts of N-(2-chloroethyl)-2-pyridinecarboxamide, 13.8 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 3.3 parts of potassium iodide and 200 parts of 4-methyl-2-pentanone is stirred and refluxed for 24 hours. The reaction mixture is evaporated and the residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (98:2 by volume) as eluent. The pure fractions are collected and the eluent is evaporated. The residue is converted into the hydrochloride salt in 2-propanol. The salt is filtered off and crystallized from ethanol, yielding 1.1 parts of N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]-2-pyridinecarboxamide dihydrochloride hydrate; mp. 250.5° C.

Provenance & Evidence