反应详情

A mixture of 7.3 parts of N-(2-bromoethyl)-4-fluoro-2-nitrobenzamide, 6.2 parts of 5-chloro-1,3-dihydro-1-(4-piperidinyl)-2H-benzimidazol-2-one, 5.2 parts of sodium carbonate and 80 parts of 4-methyl-2-pentanone is stirred and refluxed overnight. The reaction mixture is cooled, water is added and the layers are separated. The aqueous phase is extracted with 4-methyl-2-pentanone. The combined organic phases are washed with water, dried, filtered and evaporated. The residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and methanol (90:10 by volume) as eluent. The pure fractions are collected and the eluent is evaporated. The oily residue is crystallized from 2-propanone. The product is filtered off and dried, yielding 1 part of N-{2-[4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]-ethyl}-4-fluoro-2-nitrobenzamide.

1. temperaturerefluxed overnight
2. temperatureThe reaction mixture is cooled
3. customthe layers are separated
4. extractionThe aqueous phase is extracted with 4-methyl-2-pentanone
5. washThe combined organic phases are washed with water
6. customdried
7. filtrationfiltered
8. customevaporated
9. customThe residue is purified by column-chromatography over silica gel using
10. additiona mixture of trichloromethane and methanol (90:10 by volume) as eluent
11. customThe pure fractions are collected
12. customthe eluent is evaporated
13. customThe oily residue is crystallized from 2-propanone
14. filtrationThe product is filtered off
15. customdried