Methanol → HCID 68119151, compound

Participants

Reaction Steps

A mixture of 4.5 parts of N-{2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl}-2-nitrobenzamide, 80 parts of methanol and 45 parts of tetrahydrofuran is hydrogenated at normal pressure and at room temperature with 2 parts of Raney-nickel catalyst. After the calculated amount of hydrogen is taken up, the catalyst is filtered off and the filtrate is evaporated. The residue is crystallized twice from 2-propanol. The product is filtered off and dried, yielding 2 parts of 2-amino-N-{2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl}benzamide hemihydrate; mp. 219.2° C.

Provenance & Evidence