Hydrogen Peroxide → 1,3,3-Trimethyl-7-oxabicyclo-[4.1.0]heptane-2,5-dione

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Reaction Steps

2 ml of a 6 N aqueous solution of NaOH have been added during a period of 15 minutes at 15° C. to a mixture of 3,5,5-trimethyl-cyclohex-2-en-1,4-dione (3.7 g) and hydrogen hydroperoxide (8.3 ml of a 30 % solution) in 27 ml of methanol. The mixture was kept under stirring during 3 hours at 20°-25° C., treated with water and extracted with ether. The combined organic extracts were washed with water until neutrality, dried over MgSO4 and evaporated. 3.33 g (81.5 %) of the desired product, b.p. 40° C./0.001 Torr, were thus obtained.

Provenance & Evidence