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Phosgeniminium chloride → N'-(4-cyano-3-propyl-5-isothiazolyl)-N,N-dimethylchloroformamidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgeniminium chloride | HCID 2723945 | — |
| 反応物 | 5-Amino-3-propyl-4-isothiazolecarbonitrile | HCID 21426740 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N'-(4-cyano-3-propyl-5-isothiazolyl)-N,N-dimethylchloroformamidine | HCID 53949652 | 50.4% |
反応手順
In the manner of Example VI, a solution of 8.4 g of 5-amino-4-cyano-3-propylisothiazole in 50 ml of dichloromethane was treated with 9.8 g of N-(dichloromethylene)-N,N-dimethylammonium chloride. After removal of the volatile materials under reduced pressure, the residue was recrystallized from 90:10 hexane:benzene to yield 6.5 g of N'-(4-cyano-3-propyl-5-isothiazolyl)-N,N-dimethylchloroformamidine, mp 108°-109°. The ir and nmr spectra were consistent with the assigned structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04032322 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-d51fd68ff1724b3d9e11f4d4653d0b6d |
| 出典メモ | uspto-grants-1977_06 |