Methyl cis(+/-)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate → Methyl cis(+/-)-5-(4-amino-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate
Reaction equation
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[C:21]([CH3:24])=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([C:25]([O:27][CH3:28])=[O:26])[C:21]([CH3:24])=[N:22][CH:23]=2)[CH2:14][C@H:13]1[O:29][CH3:30]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The same operation as in Example (160c) was performed using methyl cis(±)-5-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-2-methylpyridine-3-carboxylate obtained in Example (171a) (225 mg) and a 10% palladium-carbon catalyst (250 mg), to obtain 113 mg of the title compound as a yellow oily substance. The resulting compound was used for the next reaction without purification.
Sources & evidence
- ORD record
- ord-84c7d78093f64319aaadf730a57d4346
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536197B2
Reaction notes
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