HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 20356579, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | Nitric Acid | HCID 944 | — |
| Reactant | N-[3-[2,4-Bis(1,1-dimethylpropyl)phenoxy]propyl]-1-hydroxy-2-naphthalenecarboxamide | HCID 13725190 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Product | HCID 20356579 | HCID 20356579 | — |
Reaction Steps
100 g of 1-hydroxy-N-[γ-(2,4-di-tert-amylphenoxy)propyl]-2-naphthamide was dissolved in 1 liter of acetic acid and nitrated at 15°-18° C. using 23 g of a 60% nitric acid aqueous solution. After the completion of the reaction, 1 liter of methanol was added thereto and precipitated crystals were separated by filtration. After recrystallization from a 2:1 by volume solvent mixture composed of ethyl acetate and methanol, 70 g of the titled compound was obtained. The melting point was 209°-210° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04032345 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-fbad754be82d4ee488db13783a1da7f7 |
| Source note | uspto-grants-1977_06 |