1H-Indole-3-thiol → 3-(Indol-3-ylthio)crotonic acid

HRID 437778Notes

Reaction equation

HRID 437778 reaction equation
[SH:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH:3]=1.[C:11]([OH:16])(=[O:15])[C:12]#[C:13][CH3:14]>>[NH:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[C:2]([S:1]/[C:13](/[CH3:14])=[CH:12]\[C:11]([OH:16])=[O:15])=[CH:3]1

Participants

3

Reactant 2

HCID 102001H-Indole-3-thiolHCID 685352-Butynoic acid

Product 1

HCID 203266063-(Indol-3-ylthio)crotonic acid

Procedure

By the same method as described in Example 1, 0.2 mole each of 3-mercaptoindole and tetrolic acid gives 10.2 g of product after recrystallization from acetonitrile, mp 201°-202° C.

Sources & evidence

ORD record
ord-7f002fc025cb411e8b0ed199dffb2c04
Source dataset
uspto-grants-1977_06
Patent number
US04032537

Reaction notes

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