Acetic Acid → HCID 178502013, compound

Participants

Reaction Steps

A solution of 6 parts of 4-(5,5-dimethyl-2-phenyl-1,3-dioxan-2yl)-1,2-benzenediamine, 4.95 parts of methyl [(methylcarbonylamino)(methylthio)methylene[carbamate and 5 parts of acetic acid in 300 parts of trichloromethane is stirred and refluxed for 24 hours. The reaction mixture is evaporated and the residue is purified by column-chromatography over silica gel using a mixture of trichloromethane and 5% of methanol as eluent. The pure fractions are collected and the eluent is evaporated, yielding 3.7 parts (48.5%) of methyl [5-(5,5-dimethyl-2-phenyl-1,3-dioxan-2-yl)-1H-benzimidazol-2-yl]carbamate; mp. 224.5° C.

Provenance & Evidence