4-Fluorophenol → HCID 22767921, compound

HRID 437810Notes

Reaction equation

HRID 437810 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[C:10]1[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:11]=1[CH:12]=[O:13].[OH-].[Na+]>O>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:10]2[CH:17]=[CH:16][C:15]([N+:18]([O-:20])=[O:19])=[CH:14][C:11]=2[CH:12]=[O:13])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 97324-FluorophenolHCID 14798Sodium HydroxideHCID 729332-Chloro-5-nitrobenzaldehyde

Product 1

HCID 22767921HCID 22767921, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

448 G. of 4-fluoro-phenol and 742 g. of 2-chloro-5-nitro-benzaldehyde are added to a solution of 184 g. of sodium hydroxide in 7.4 liters of water. The mixture is then left to cool to room temperature. The precipitate is removed by filtration, washed carefully with water, and there is obtained 2-(4-fluoro-phenoxy)-5-nitro-benzaldehyde, having a melting point of 125°-126° C.

Workup

  1. waitThe mixture is then left
  2. customThe precipitate is removed by filtration
  3. washwashed carefully with water

Sources & evidence

ORD record
ord-773c22f2aa5d4c4182bd1d939f0380db
Source dataset
uspto-grants-1977_06
Patent number
US04032525

Reaction notes

Loading…