3-(2-Chloroethyl)-1,3-oxazolidin-2-one → HCID 22767936, compound

HRID 437818Notes

Reaction equation

HRID 437818 reaction equation
[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]3)[CH2:10][C:4]=2[CH:3]=1.Cl[CH2:24][CH2:25][N:26]1[CH2:30][CH2:29][O:28][C:27]1=[O:31]>>[Br:1][C:2]1[CH:22]=[CH:21][C:5]2[O:6][C:7]3[CH:20]=[CH:19][CH:18]=[CH:17][C:8]=3[CH:9]([N:11]3[CH2:12][CH2:13][N:14]([CH2:24][CH2:25][N:26]4[CH2:30][CH2:29][O:28][C:27]4=[O:31])[CH2:15][CH2:16]3)[CH2:10][C:4]=2[CH:3]=1

Participants

3

Reactant 2

HCID 756333-(2-Chloroethyl)-1,3-oxazolidin-2-oneHCID 22767871HCID 22767871, compound

Product 1

HCID 22767936HCID 22767936, compound

Procedure

In an analogous manner to that described in Example 6, from 1-[2-bromo-10,11-dihydro-dibenz[b,f]oxepin-10-yl]-piperazine and 3-(2-chloro-ethyl)-2-oxazolidinone, there is obtained 3-[2-{4-[2-bromo-10,11 -dihydro-dibenz[b,f]oxepin-10-yl]-1-piperazinyl}-ethyl]-2-oxazolidinone having a melting point of 150°-152° C. The dihydrochloride, prepared in ethanol, melts at 175°-176° C.

Sources & evidence

ORD record
ord-f0f5a4c8ab074badba750296ab844b5a
Source dataset
uspto-grants-1977_06
Patent number
US04032525

Reaction notes

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