反应详情

136 G. of 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid are boiled at reflux for 2.5 hours in a mixture of 1000 ml. of methanol and 100 ml. of concentrated sulfuric acid. After concentration of the mixture under vacuum, the residue is poured on to ice and extracted with benzene. The benzene extracts are washed with water, aqueous sodium bicarbonate solution and again with water. After evaporation of the benzene, there is obtained 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid methyl ester in the form of an oil.

1. temperatureat reflux for 2.5 hours in a mixture of 1000 ml
2. additionAfter concentration of the mixture under vacuum, the residue is poured on to ice
3. extractionextracted with benzene
4. washThe benzene extracts are washed with water, aqueous sodium bicarbonate solution and again with water
5. customAfter evaporation of the benzene