HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 437879Generated: October 30, 2026
Benzoic Acid → 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide
https://huagongshe.com/reaction/437879
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N~1~,N~1~,N~3~,N~3~-Tetraethylbenzene-1,3-diamine | HCID 19382815 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide | HCID 53894173 | — |
Reaction Steps
A mixture of 2-(4-dimethylamino)benzoyl)benzoic acid (8.07 g.), N,N,N',N'-tetraethyl-m-phenylenediamine (7.26 g.) and acetic anhydride (5 ml.) was heated (at 52° C.) during one and one-half hours. Addition of methanol (10 ml., then 15 ml.) afforded 3-(2,4-bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)phthalide (I: X= (CH3CH2)2N, Y2 = Z4 = Z5 = Z6 = Z7 = H, Y4 = (CH3)2N) (10.92 g., m.p. 117°- 119° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04032527 |
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| Source dataset | uspto-grants-1977_06 |
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| ORD ID | ord-f3142030a80c428ab38720aeb89ea988 |
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| Source note | uspto-grants-1977_06 |
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