HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 437885Generated: October 30, 2026
Acetic Anhydride → 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)-4,5,6,7-tetrachlorophthalide
https://huagongshe.com/reaction/437885
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | N~1~,N~1~,N~3~,N~3~-Tetraethylbenzene-1,3-diamine | HCID 19382815 | — |
| Reactant | HCID 20287184 | HCID 20287184 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2,4-Bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)-4,5,6,7-tetrachlorophthalide | HCID 54142190 | — |
Reaction Steps
A mixture of 2-(4-(dimethylamino)benzoyl)-3,4,5,6-tetrachlorobenzoic acid (16.28 g.), N,N,N',N'-tetraethyl-m-phenylenediamine (9.68 g.) and acetic anhydride (10 ml.) was heated (at 91° C.) during two hours. Addition of methanol (20 ml., then 12 ml., then 10 ml.) afforded 3-(2,4-bis(diethylamino)phenyl)-3-(4-(dimethylamino)phenyl)-4,5,6,7-tetrachlorophthalide (I: X= (CH3CH2)2N, Y2 = H, Y4 = (CH3)2N, Z4 = Z5 = Z6 = Z7 = Cl) in three fractions (m.p. 174°- 176° C., m.p. 180° -181° C. and m.p. 180° -181° C.).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04032527 |
|---|
| Source dataset | uspto-grants-1977_06 |
|---|
| ORD ID | ord-cc8ecd1e79974c8fb82d9596632b4a58 |
|---|
| Source note | uspto-grants-1977_06 |
|---|
