Ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoate → Ethyl 2-propyl-5-thiazole-pentanoate

HRID 437945Notes

Reaction equation

HRID 437945 reaction equation
[H][H].[CH2:3]([C:6]1[S:7][C:8]([CH:11]=[CH:12][CH:13]=[CH:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][N:10]=1)[CH2:4][CH3:5]>C(O)C>[CH2:3]([C:6]1[S:7][C:8]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]([O:17][CH2:18][CH3:19])=[O:16])=[CH:9][N:10]=1)[CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 54337588Ethyl 5-(2-propyl-5-thiazolyl)2,4-pentadienoateHCID 178418361HCID 178418361, compound

Product 1

HCID 20369849Ethyl 2-propyl-5-thiazole-pentanoateYield 90.5%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Hydrogen was added with stirring for 2 hours to a mixture of 25 g of ethyl 5-(2-propyl-5-thiazolyl)-2,4-pentadienoate, 250 ml of ethanol and 12.5 g of activated carbon containing 10% palladium and the mixture was filtered. The fiter was washed with ethanol and the filtrate was evaporated to dryness under reduced pressure to obtain 23 g of raw ethyl 2-propyl- 5-thiazolepentanoate.

Workup

  1. filtrationthe mixture was filtered
  2. washThe fiter was washed with ethanol
  3. customthe filtrate was evaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-e57ac2705b344bbfaf3e01f68c33df45
Source dataset
uspto-grants-1977_06
Patent number
US04032643

Reaction notes

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