Sodium Hydroxide → HCID 20378662, compound

HRID 437956Notes

Reaction equation

HRID 437956 reaction equation
[C:1]([N:11]1[CH2:32][CH2:31][N:14]2[C:15]3[C:20]([NH:21][C:22](=[O:23])[CH:13]2[CH2:12]1)=[CH:19][C:18]([NH:24]C(=O)C(F)(F)F)=[CH:17][CH:16]=3)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].[OH-].[Na+]>O>[NH2:24][C:18]1[CH:19]=[C:20]2[C:15](=[CH:16][CH:17]=1)[N:14]1[CH2:31][CH2:32][N:11]([C:1]([O:3][CH2:4][C:5]3[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=3)=[O:2])[CH2:12][CH:13]1[C:22](=[O:23])[NH:21]2

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 20378647HCID 20378647, compound

Product 1

HCID 20378662HCID 20378662, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 2.8 g. of 3-carbobenzoxy-2,3,4,4a-Tetrahydro-8-(2,2,2-trifluoroacetamido)-1H-pyrazino[1,2-a] quinoxalin-5(6H)-one, 0.5 g. sodium hydroxide and 200 ml. of water is boiled for 15 minutes, then cooled. The mixture is then extracted with methylene chloride. The organic portion is then extracted with dilute hydrochloric acid. The aqueous acid phase is then basified with dilute sodium hydroxide and extracted with methylene chloride. The organic phase is dried and concentrated to give 1.6 g. of pale yellow solid product, m.p. 130°-135°.

Workup

  1. additionA mixture of 2.8 g
  2. temperaturecooled
  3. extractionThe mixture is then extracted with methylene chloride
  4. extractionThe organic portion is then extracted with dilute hydrochloric acid
  5. extractionextracted with methylene chloride
  6. customThe organic phase is dried
  7. concentrationconcentrated
  8. customto give 1.6 g

Sources & evidence

ORD record
ord-289794fe42e0499398e93666e19dbb50
Source dataset
uspto-grants-1977_06
Patent number
US04032639

Reaction notes

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