HCID 20378662, compound → HCID 20378672, compound

Participants

Reaction Steps

A mixture of 1.5 g. of 8-amino-3-carbobenzoxy-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a] quinoxalin-5(6H)-one, 1.5 g. of 10% Palladium on carbon catalyst and 150 ml. of ethanol is hydrogenated for 1/2 hour at 45 p.s.i. The catalyst is filtered and the filtrate concentrated to a volume of 50 ml. Ethanolic hydrochloric acid is added, and the product precipitates as the hydrochloric salt. Weight of product 0.70 g., m.p. 294°-295° dec. Recrystallization from ethanol-water gives 0.45 g. of pure product, m.p. 315°-317° dec.

Provenance & Evidence