Bromine → HCID 10611006, compound

HRID 437990Notes

Reaction equation

HRID 437990 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[C:5]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)(=[O:11])[CH2:6][CH2:7][CH2:8][CH2:9][CH3:10].[Br:18]Br>CCOCC>[Br:18][CH:6]([CH2:7][CH2:8][CH2:9][CH3:10])[C:5]([C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1)=[O:11]

Participants

5

Reactant 3

HCID 24408BromineHCID 70337HexanophenoneHCID 6451240Aluminum(III) Chloride

Product 1

HCID 10611006HCID 10611006, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Anhydrous aluminum chloride (0.120 g.) is added to an ice-cooled solution of n-hexanophenone (21.1 g.) in anhydrous ether (20 ml.). The mixture is stirred and ice-cooled to a temperature below 10° C. during the dropwise addition of bromine (6.0 ml.) during 1 hour. The mixture is evaporated and the residual oil dissolved in ether (100 ml.). The solution obtained is washed first with a saturated aqueous solution of sodium thiosulphate (3× 30 ml.) and then with water. After drying (sodium sulphate) the ethereal solution is evaporated to give α-bromo-n-hexanophenone as an oil (28.0 g.) which is used without further purification.

Workup

  1. customThe mixture is evaporated
  2. dissolutionthe residual oil dissolved in ether (100 ml.)
  3. customThe solution obtained
  4. washis washed first with a saturated aqueous solution of sodium thiosulphate (3× 30 ml.)
  5. dry with materialAfter drying (sodium sulphate) the ethereal solution
  6. customis evaporated

Sources & evidence

ORD record
ord-cdc8598f3b03490b825c7365e663d583
Source dataset
uspto-grants-1977_06
Patent number
US04032651

Reaction notes

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