HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → N-(5-carboxy-2,3,4,5-tetrahydroxy-pentyl)-L-(+)-glutamic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | L-Glutamic Acid | HCID 33032 | — |
| Reactant | Glucuronic Acid | HCID 65041 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-(5-carboxy-2,3,4,5-tetrahydroxy-pentyl)-L-(+)-glutamic acid | HCID 54046356 | — |
Reaction Steps
As starting material D-glucuronic acid and L-(+)-glutamic acid were used. The reductive amination was carried out using Raney nickel as a catalyst and heating for 2 hours to 50° C. and for 4 hours to 70° C. The product obtained had a melting point of 90° C. (with sintering) an RF -value of 0.70 (determined on DC-finished plates of silica gel G (Merck) with a transporting liquid made up of 70 parts by volume of methanol and 30 parts by volume of water).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04032676 |
| Source dataset | uspto-grants-1977_06 |
| ORD ID | ord-91fdf7bb5232460c8b88feb0fe6abf61 |
| Source note | uspto-grants-1977_06 |