Butanal → HCID 21427377, compound

Participants

Reaction Steps

A mixture of 0.5 mole each of triphenyl phosphite, n-butyraldehyde and p-toluenesulfonamide in 150 g of chlorobenzene is stirred and warmed under nitrogen. An exothermic reaction is detectable at 85° C., and cooling is used for a few minutes to keep the temperature below 93°. Heating is then continued at 95°-100° for 0.75 hr to ensure complete reaction. The reaction mixture is cooled to 25° and filtered. The product is recrystallized from acetonitrile, giving 202 g (88% yield) of white solid: mp 178°-180°; 31P nmr(DMSO-d6)- 17.7 ppm.

Provenance & Evidence