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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 43857Generated: October 29, 2026

Sodium Carbonate → HCID 86648793, compound

https://huagongshe.com/reaction/43857

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium CarbonateHCID 10340—
ReactantEthyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylateHCID 2824057—
ReactantHCID 86648790HCID 86648790—
ProductHCID 86648793HCID 8664879385%

Reaction Steps

The same operation as in Example (196c) was performed using trans(±)-4-chloro-5-ethyl-N-[3-(propylamino)piperidin-4-yl]-1H-imidazole-2-carboxamide obtained in Example (205a) (10.0 mg, 0.032 mmol), ethyl 2-bromo-4-methyl-1,3-thiazole-5-carboxylate (9 mg, 0.035 mmol) and sodium carbonate (10 mg, 0.096 mmol), to obtain 13 mg of the title compound (85%) as a colorless solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08536197B2
Source datasetuspto-grants-2013_09
ORD IDord-e20dbf6d685d4b76afb18464b85e4121
Source noteuspto-grants-2013_09