Sodium Carbonate → Ethyl cis(+/-)-2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(ethylamino)piperidin-1-yl)-1,3-benzothiazole-7-carboxylate

Participants

Reaction Steps

The same operation as in Example (196c) was performed using tert-butyl cis(±)-4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl]amino}-3-(ethylamino)piperidine-1-carboxylate obtained in Example (207a) (23.0 mg, 0.058 mmol), 4 N hydrochloric acid/1,4-dioxane (1 mL), ethyl 2-bromo-1,3-benzothiazole-7-carboxylate obtained in Example (1f) (20 mg, 0.069 mmol) and sodium carbonate (61 mg, 0.575 mmol), to obtain 13 mg of the title compound (45%) as a colorless solid.

Provenance & Evidence