cis(+/-)-3-(tert-Butoxycarbonyl)amino-1-(diphenylmethyl)-2-ethylazetidine → cis(+/-)-3-(tert-Butoxycarbonyl)amino-2-ethylazetidine
Reaction equation
[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:12][N:11](C(C2C=CC=CC=2)C2C=CC=CC=2)[C@H:10]1[CH2:26][CH3:27])=[O:7])([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6]([NH:8][C@H:9]1[CH2:12][NH:11][C@H:10]1[CH2:26][CH3:27])=[O:7])([CH3:4])([CH3:3])[CH3:2]Participants
3
Reactant 1
Product 1
Reagents, catalysts & solvents 1
Procedure
The same operation as in Example (234e) was performed using cis(±)-3-(tert-butoxycarbonyl)amino-1-(diphenylmethyl)-2-ethylazetidine obtained in Example (235e) (154 mg, 0.42 mmol) and 10% Pd/C (30 mg), to obtain 66 mg of the title compound as a white solid (79%).
Sources & evidence
- ORD record
- ord-282e1c91603046109f34c85a3b05228e
- Source dataset
- uspto-grants-2013_09
- Patent number
- US08536197B2
Reaction notes
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