HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 2-Dimethylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 2-Thiopheneacetonitrile, a-amino-, monohydrochloride | HCID 13352456 | — |
| Reactant | 2-(Dimethylamino)-4-methyl-1,3-thiazole-5-carboxylic acid | HCID 23509747 | — |
| Reactant | 2-(Dimethylamino)-4-methyl-1,3-thiazole-5-carbonyl chloride | HCID 45081874 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Dimethylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide | HCID 53640191 | 36% |
Reaction Steps
1.2g of 2-dimethylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-dimethylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.3g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 1.1g of amino-thiophen-2-yl-acetonitrile hydrochloride and 2.5ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.65g (Yield 36%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05514643 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-24a62718899f49e6b83846e1bfde1c01 |
| Source note | uspto-grants-1996_05 |