HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 2-t-Butylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 2-t-Butylamino-4-methyl-thiazole-5-carboxylic acid | HCID 9154702 | — |
| Reactant | 2-Thiopheneacetonitrile, a-amino-, monohydrochloride | HCID 13352456 | — |
| Reactant | 2-t-Butylamino-4-methyl-thiazole-5-carboxylic acid chloride | HCID 54169603 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-t-Butylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide | HCID 54145706 | 41% |
Reaction Steps
1.5g of 2-t-butylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-t-butylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.6g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 1.4g of amino-thiophen-2-yl-acetonitrile hydrochloride and 3.3ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.96g (Yield 41%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05514643 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-901ba6a8ae6d427db531ead943d298b2 |
| Source note | uspto-grants-1996_05 |