HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus pentachloride → 2-Methoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus pentachloride | HCID 24819 | — |
| Reactant | 2-Thiopheneacetonitrile, a-amino-, monohydrochloride | HCID 13352456 | — |
| Reactant | 2-Methoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid | HCID 22411064 | — |
| Reactant | 2-Methoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid chloride | HCID 54062599 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 2-Methoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide | HCID 54515855 | 32.1% |
Reaction Steps
1.7g of 2-methoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-methoxycarbonylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.8g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 1.5g of amino-thiophen-2-yl-acetonitrile hydrochloride and 2.4ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.85g (Yield 32%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05514643 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-bb809b9696024e2887f4202f6cf519b4 |
| Source note | uspto-grants-1996_05 |