Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Phosphorus pentachloride → 2-Cyclopropylamino-4-methyl-thiazole-5-carboxylic acid (cyano-furan-2-yl-methyl)-amide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Phosphorus pentachloride | HCID 24819 | — |
| 반응물 | HCID 13075762 | HCID 13075762 | — |
| 반응물 | 2-(Cyclopropylamino)-4-methyl-1,3-thiazole-5-carboxylic acid | HCID 22411062 | — |
| 반응물 | 2-Cyclopropylamino-4-methyl-thiazole-5-carboxylic acid chloride | HCID 54454460 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 2-Cyclopropylamino-4-methyl-thiazole-5-carboxylic acid (cyano-furan-2-yl-methyl)-amide | HCID 54463436 | 38.9% |
반응 단계
1.4g of 2-cyclopropylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-cyclopropylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.6g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 1.2g of amino-furan-2-yl-acetonitrile hydrochloride and 3.2ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.83g (Yield 35%) of the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05514643 |
| 출처 데이터셋 | uspto-grants-1996_05 |
| ORD ID | ord-ef0b9783dd61415194e92ee385f16e06 |
| 출처 메모 | uspto-grants-1996_05 |