Ethylamine → HCID 54408101, compound

Participants

Reaction Steps

1.0g of 2-bromo-4-trifluoromethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide, 0.36ml of triethylamine and 0.50ml of ethylamine were added to 10ml of tetrahydrofuran and the reaction mixture was stirred under reflux for 4 hours. Water and ethylacetate were added thereto to separate the layers. The separated organic layer was dried over anhydrous sodium sulfate and evaporated. The residue was recrystallized from the mixed solvent of n-hexane and ethylacetate to obtain 0.67g (Yield 73%) of the title compound.

Provenance & Evidence