HuagongsheHuagongshe Chemistry Print Report · For research reference only
Allylamine → 2-Allylamino-4-ethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Allylamine | HCID 7853 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 54448843 | HCID 54448843 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Allylamino-4-ethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide | HCID 54215084 | 61% |
Reaction Steps
1.0g of 2-bromo-4-ethyl-thiazole-5-carboxylic acid (cyano-thiophen-2-yl-methyl)-amide, 0.40ml of triethylamine and 0.66ml of allylamine were added to 10ml of tetrahydrofuran. The reaction mixture was stirred under reflux for 12 hours and then treated according to the same procedure as EXAMPLE 10 to obtain 0.57g (Yield 61%) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05514643 |
| Source dataset | uspto-grants-1996_05 |
| ORD ID | ord-735d849a1a0044fdb959ede3a4b42345 |
| Source note | uspto-grants-1996_05 |