反应详情

A mixture of 3-hydroxy-4-nitrobenzoic acid (10 g, 55 mmole) in acetic anhydride (20 ml) and anhydrous pyridine (20 ml) was refluxed for 4 hours. The reaction mixture was poured onto ice and the resulting mixture was extracted with ethyl acetate (2×100 ml). The organic layer was washed successively with dilute Hcl solution (2×100 ml) and saturated brine solution, dried over Na2SO4, filtered and evaporated to give 3-acetoxy-4-nitrobenzoic acid.

1. temperaturewas refluxed for 4 hours
2. additionThe reaction mixture was poured onto ice
3. extractionthe resulting mixture was extracted with ethyl acetate (2×100 ml)
4. washThe organic layer was washed successively
5. additionwith dilute Hcl solution (2×100 ml) and saturated brine solution
6. dry with materialdried over Na2SO4
7. filtrationfiltered
8. customevaporated