4-Methylmorpholine → Ethyl 2-(4-{[(4-chloro-5-ethyl-1H-imidazol-2-yl)carbonyl](methyl)amino}piperidin-1-yl)-4-methyl-1,3-thiazole-5-carboxylate

Participants

Reaction Steps

The same operation as in Example (217c) was performed using ethyl 4-methyl-2-[4-(methylamino)piperidin-1-yl]-1,3-thiazole-5-carboxylate obtained in Example (240b) (254 mg, 0.90 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (156 mg, 0.90 mmol), WSC hydrochloride (515 mg, 2.69 mmol), 1-hydroxybenzotriazole (121 mg, 0.90 mmol) and N-methylmorpholine (0.20 mL, 1.79 mmol), to obtain 366 mg of the title compound as a white solid (93%).

Provenance & Evidence