Benzenesulfonyl chloride → HCID 15453200, compound

Participants

Reaction Conditions

Reaction Steps

3-Amino-4-bromo-5-tert-butylisoxazole (219 mg, 1.0 mmol)was dissolved in dry pyridine (1 ml). Benzenesulfonyl chloride (0.14 ml, 1.1 mmol) and 4-dimethylamino-pyridine (5 mg) were added and the solution was stirred at 50 ° C. for 6 h. The reaction mixture was diluted with dichloromethane (75 ml), washed with 1N HCl (50 ml) and dried over anhydrous magnesium sulfate. The solvent was removed under reduced pressure to yield a crude product, which was purified by column chromatography (9:1 hexanes/ethyl acetate). A crystalline solid was obtained after recrystallization from ethyl acetate/hexanes, m.p. 139°-141° C.

Provenance & Evidence